DDI1

Across TCGA pan-cancer cohorts, DDI1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DDI1 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher DDI1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDI1 expression acts as an unfavorable survival marker.

KICH, SCLC, and OV are the cancer types where DDI1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.025	0.904	<.001	36	view →
SCLC	OS	Median	II,III,IV	0.082	0.702	<.001	24	view →
OV	OS	Median	II,III,IV	0.330	0.843	.002	18	view →
GBM	DFS	Median	All	0.068	0.288	.003	6	view →
LGG	OS	Median	All	0.182	0.909	<.001	6	view →
ESCA	OS	Median	III,IV	0.136	0.573	.023	6	view →
SKCM	DFS	Median	All	0.083	0.211	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DDI1–KICH (DFS)

Open the KICH breakdown →