DDI1

Across TCGA patient cohorts, DDI1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDI1-associated genes across cancer lineages are Caspase-7-cleavedD198, ERCC1, and NF2. Each is linked with DDI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DDI1-to-partner and partner-to-DDI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DDI1-low versus DDI1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDI1→partner) and Y-score (partner→DDI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.224	+2.423	<.001	.001	3	4
COAD	ERCC1 →	+0.161	+2.321	.009	.033	3	3
COAD	NF2 →	+0.158	+1.749	.024	.049	3	3
UCEC	eEF2 →	+0.308	+1.847	.019	.008	3	3
UCEC	ATM →	-0.457	-2.446	.006	.018	3	3
LUSC	ERK2 →	+0.330	+2.816	.041	.036	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Caspase-7-cleavedD198 by DDI1 expression — COAD

Explore this box plot interactively →