DDI1

Across TCGA cell cohorts, DDI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 559 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDI1-associated GO terms across cancer lineages are Negative regulation of amyloid-beta formation, Regulation of protein localization to Cajal body, and Positive regulation of protein localization to Cajal body. Each is linked with DDI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DDI1-to-partner and partner-to-DDI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of amyloid-beta formation grouped by DDI1-low versus DDI1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDI1→partner) and Y-score (partner→DDI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of amyloid-beta formation →	+0.070	+0.007	.006	<.001	3	4
BLOOD_Leukemia	Regulation of protein localization to Cajal body →	+0.036	+0.007	.001	.004	3	4
BLOOD_Leukemia	Positive regulation of protein localization to Cajal body →	+0.036	+0.007	.001	.004	3	4
BLOOD_Leukemia	Negative regulation of mRNA splicing, via spliceosome →	+0.041	+0.007	.009	.003	3	4
BLOOD_Leukemia	Negative regulation of mRNA processing →	+0.044	+0.010	.004	.001	3	4
BLOOD_Leukemia	Cellular response to anisomycin →	-0.082	-0.005	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 559 associations by consensus.

Negative regulation of amyloid-beta formation by DDI1 expression — BLOOD_Leukemia

Explore this box plot interactively →