DDI1

Across TCGA cell cohorts, DDI1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDI1-associated genes across cancer lineages are OR1L3, ASB17, and C12orf40. Each is linked with DDI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDI1-to-partner and partner-to-DDI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by DDI1-low versus DDI1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDI1→partner) and Y-score (partner→DDI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
SKIN	BTN1A1 →	+0.216	+4.095	<.001	.009	3	1
SKIN	ODF1 →	+0.020	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OR1L3 by DDI1 expression — SKIN

Explore this box plot interactively →