DDC

Across TCGA pan-cancer cohorts, DDC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DDC data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DDC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DDC expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and PDAC are the cancer types where DDC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.796	0.402	<.001	98	view →
COAD	DFS	Median	All	1.000	0.884	.017	24	view →
PDAC	OS	Median	II,III,IV	0.901	0.786	.015	10	view →
LUAD	OS	Median	III,IV	0.887	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DDC–CCRCC (DFS)

Open the CCRCC breakdown →