DDC

Across TCGA patient cohorts, DDC mutation is significantly associated with the RNA expression of many other genes, with 1,738 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDC-associated genes across cancer lineages are PCBD1, RAD23A, and PPP1R14BP3. Each is linked with DDC in more than 1 cancer types. Because this analysis shows association rather than direction, both DDC-to-partner and partner-to-DDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCBD1 grouped by DDC-low versus DDC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDC→partner) and Y-score (partner→DDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCBD1 →	+0.332	+2.502	.004	.001	3	2
SKCM	RAD23A →	+0.278	+2.089	.003	.001	3	2
SKCM	PPP1R14BP3 →	+0.460	+2.128	.003	.009	3	2
UCEC	RPL23AP82 →	+0.513	+3.008	<.001	<.001	3	2
SKCM	ZNF763 →	-0.298	-2.367	.003	.003	3	2
UCEC	FLVCR1-DT →	+0.418	+2.098	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,738 associations by consensus.

PCBD1 by DDC expression — SKCM

Explore this box plot interactively →