DDC

Across TCGA cell cohorts, DDC mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDC-associated genes across cancer lineages are OR9A2, SIX6, and PRAMEF9. Each is linked with DDC in more than 1 cancer types. Because this analysis shows association rather than direction, both DDC-to-partner and partner-to-DDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A2 grouped by DDC-low versus DDC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDC→partner) and Y-score (partner→DDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR9A2 →	+0.028	+4.133	.002	.003	3	1
BLOOD_Leukemia	SIX6 →	+1.789	+3.769	<.001	.008	3	1
BLOOD_Leukemia	PRAMEF9 →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.027	+4.384	<.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR9A2 by DDC expression — BLOOD_Leukemia

Explore this box plot interactively →