Across TCGA pan-cancer cohorts, DDC-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated DDC-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher DDC-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DDC-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KICH, STAD, and BLCA are the cancer types where DDC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	II,III,IV	0.070	0.828	<.001	63	view →
STAD	OS	Tertile	All	0.340	0.657	.004	57	view →
BLCA	DFS	Tertile	III,IV	0.186	0.578	.001	54	view →
KIRC	DFS	Tertile	IV	0.469	0.218	.003	44	view →
LUAD	OS	Tertile	All	0.718	0.827	.005	42	view →
LGG	DFS	Median	All	0.578	0.387	.002	32	view →
ESCA	OS	Quartile	All	0.470	1.000	<.001	27	view →
KIRP	DFS	Median	III,IV	0.847	0.213	.005	26	view →
SARC	OS	Tertile	All	0.476	0.761	<.001	24	view →
LAML	DFS	Tertile	All	0.190	0.594	.012	18	view →
CHOL	OS	Tertile	All	0.089	0.673	.018	18	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

Exploration

Same gene, other analysis: DDC-AS1 tumor-vs-normal RNA expression · all DDC-AS1 data types