DDB2

Across TCGA patient cohorts, DDB2 mutation is significantly associated with the RNA expression of many other genes, with 821 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDB2-associated genes across cancer lineages are SLC29A4P1, MIR4510, and RNA5SP72. Each is linked with DDB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDB2-to-partner and partner-to-DDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC29A4P1 grouped by DDB2-low versus DDB2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDB2→partner) and Y-score (partner→DDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SLC29A4P1 →	+0.060	+5.867	<.001	.003	3	2
CESC	MIR4510 →	+0.400	+6.342	<.001	.001	3	2
BRCA	RNA5SP72 →	+0.204	+5.459	<.001	.001	3	2
BRCA	RNU7-165P →	+0.476	+4.540	<.001	.001	3	2
BLCA	RNF152P1 →	+0.285	+3.970	<.001	<.001	3	2
UCEC	IGHD4-17 →	+0.622	+2.714	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 821 associations by consensus.

SLC29A4P1 by DDB2 expression — SKCM

Explore this box plot interactively →