DDB2

Across TCGA patient cohorts, DDB2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDB2-associated genes across cancer lineages are p62 Lck ligand, Caspase-7-cleavedD198, and CD20. Each is linked with DDB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDB2-to-partner and partner-to-DDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by DDB2-low versus DDB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDB2→partner) and Y-score (partner→DDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.390	+2.999	.013	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.658	+2.827	.021	.035	3	1
UCEC	CD20 →	+0.136	+3.020	.032	.019	3	1
UCEC	PCNA →	+0.269	+3.584	.010	.002	2	1
UCEC	VHL →	-0.819	-3.000	.012	.036	2	1
UCEC	p27_pT198 →	+0.154	+2.459	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

p62 Lck ligand by DDB2 expression — UCEC

Explore this box plot interactively →