DDB2

Across TCGA cell cohorts, DDB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,477 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDB2-associated GO terms across cancer lineages are Regulation of cardiolipin metabolic process, Glomerular mesangial cell development, and Mesangial cell development. Each is linked with DDB2 in more than 10 cancer types. Because this analysis shows association rather than direction, both DDB2-to-partner and partner-to-DDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cardiolipin metabolic process grouped by DDB2-low versus DDB2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDB2→partner) and Y-score (partner→DDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of cardiolipin metabolic process →	-0.222	-1.581	<.001	<.001	3	11
LARGE_INTESTINE	Glomerular mesangial cell development →	+0.781	+1.040	.001	<.001	3	10
PANCREAS	Mesangial cell development →	+0.923	+0.965	<.001	<.001	3	10
BLOOD_Leukemia	Negative regulation of DNA biosynthetic process →	+0.069	+0.910	<.001	<.001	3	9
SKIN	Response to vitamin B1 →	+0.136	+1.112	<.001	<.001	3	9
LARGE_INTESTINE	Cellular response to cell-matrix adhesion →	+0.263	+0.889	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,477 associations by consensus.

Regulation of cardiolipin metabolic process by DDB2 expression — KIDNEY

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