DDB1

Across TCGA pan-cancer cohorts, DDB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DDB1 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DDB1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DDB1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where DDB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.760	0.912	.008	23	view →
LSCC	OS	Quartile	All	0.891	0.677	.017	10	view →
GBM	DFS	Tertile	All	0.491	0.259	.002	8	view →
LUAD	DFS	Tertile	II,III,IV	0.324	0.725	.022	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
CCRCC	DFS	Quartile	All	1.000	0.530	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DDB1–HNSC (OS)

Open the HNSC breakdown →