DDB1

Across TCGA patient cohorts, DDB1 mutation is significantly associated with the RNA expression of many other genes, with 5,640 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDB1-associated genes across cancer lineages are RNU7-77P, AATF, and UHRF1. Each is linked with DDB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDB1-to-partner and partner-to-DDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-77P grouped by DDB1-low versus DDB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDB1→partner) and Y-score (partner→DDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU7-77P →	+0.340	+2.099	.001	.008	3	3
UCEC	AATF →	+0.371	+2.192	<.001	<.001	3	3
UCEC	UHRF1 →	+0.847	+2.203	<.001	<.001	3	3
LIHC	RNU6-142P →	+0.375	+6.479	<.001	.001	3	3
COAD	RN7SL567P →	+0.288	+4.053	<.001	.001	3	3
UCEC	CHEK1 →	+0.789	+2.214	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,640 associations by consensus.

RNU7-77P by DDB1 expression — SKCM

Explore this box plot interactively →