DDB1

Across TCGA patient cohorts, DDB1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDB1-associated genes across cancer lineages are Notch1, ASNS, and Caspase-7-cleavedD198. Each is linked with DDB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDB1-to-partner and partner-to-DDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DDB1-low versus DDB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDB1→partner) and Y-score (partner→DDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.136	+1.691	.001	.011	3	3
UCEC	ASNS →	+0.362	+1.847	.001	.007	3	3
UCEC	Caspase-7-cleavedD198 →	+0.383	+1.300	.037	.034	3	3
UCEC	c-Kit →	-0.150	-1.415	.038	.010	3	3
UCEC	eIF4E →	+0.191	+2.820	.003	.001	3	2
UCEC	INPP4B →	-0.265	-2.502	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Notch1 by DDB1 expression — UCEC

Explore this box plot interactively →