DDB1

Across TCGA cell cohorts, DDB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,971 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDB1-associated GO terms across cancer lineages are Regulation of attachment of mitotic spindle microtubules to kinetochore, Positive regulation of attachment of mitotic spindle microtubules to kinetochore, and mRNA alternative polyadenylation. Each is linked with DDB1 in more than 16 cancer types. Because this analysis shows association rather than direction, both DDB1-to-partner and partner-to-DDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of attachment of mitotic spindle microtubules to kinetochore grouped by DDB1-low versus DDB1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDB1→partner) and Y-score (partner→DDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.136	+0.489	.002	.002	3	17
SOFT_TISSUE	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.153	+0.669	<.001	<.001	3	17
STOMACH	mRNA alternative polyadenylation →	+0.109	+0.685	.001	<.001	3	15
URINARY_TRACT	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.143	+0.632	.001	.004	3	15
PANCREAS	Regulation of metaphase plate congression →	+0.109	+0.679	.001	<.001	3	15
BLOOD_Myeloma	DNA-templated transcription initiation →	+0.057	+0.898	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,971 associations by consensus.

Regulation of attachment of mitotic spindle microtubules to kinetochore by DDB1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →