DDB1

Across TCGA cell cohorts, DDB1 mutation is significantly associated with the RNA expression of many other genes, with 662 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDB1-associated genes across cancer lineages are C4orf36, ATP2A1, and DPRX. Each is linked with DDB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDB1-to-partner and partner-to-DDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf36 grouped by DDB1-low versus DDB1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDB1→partner) and Y-score (partner→DDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C4orf36 →	+0.539	+3.260	<.001	.005	3	2
BLOOD_Leukemia	ATP2A1 →	+0.860	+3.199	<.001	.007	3	2
BLOOD_Leukemia	DPRX →	+0.050	+2.890	<.001	.003	3	2
BLOOD_Leukemia	IQCF5 →	+0.037	+2.979	<.001	.007	3	2
LARGE_INTESTINE	TRIM35 →	+0.654	+2.588	<.001	.004	3	2
LARGE_INTESTINE	TTC33 →	+0.574	+2.502	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 662 associations by consensus.

C4orf36 by DDB1 expression — BLOOD_Leukemia

Explore this box plot interactively →