Across TCGA patient cohorts, DDAH2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDAH2-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with DDAH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDAH2-to-partner and partner-to-DDAH2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDAH2→partner) and Y-score (partner→DDAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.240	-2.584	.040	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.166	-2.449	.004	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.227	-2.571	.003	.011	3	1
UCEC	JNK2 →	+0.243	+2.817	.008	.036	3	1
UCEC	Ku80 →	+0.393	+2.598	<.001	.006	3	1
UCEC	mTOR_pS2448 →	-0.218	-3.302	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

DDAH2 survival (RNA) · tumor vs normal (RNA) · all DDAH2 data types