DDAH1

Across TCGA patient cohorts, DDAH1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDAH1-associated genes across cancer lineages are Notch1, FOXO3a_pS318_S321, and HER3_pY1289. Each is linked with DDAH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDAH1-to-partner and partner-to-DDAH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DDAH1-low versus DDAH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDAH1→partner) and Y-score (partner→DDAH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.214	+3.087	<.001	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.139	-2.000	.005	.029	3	1
UCEC	HER3_pY1289 →	+0.097	+1.894	.005	.030	3	1
UCEC	IRS1 →	+0.189	+1.906	.023	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-2.401	.002	.003	3	1
UCEC	JNK2 →	+0.296	+2.594	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by DDAH1 expression — UCEC

Explore this box plot interactively →