DCUN1D2

Across TCGA pan-cancer cohorts, DCUN1D2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DCUN1D2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where DCUN1D2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DCUN1D2 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where DCUN1D2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCUN1D2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	−0.707	<.001	5	view →
LUAD	Male	All	−0.382	<.001	4	view →
CCRCC	Male	All	−0.560	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

DCUN1D2–LSCC

Open the LSCC breakdown →