DCUN1D1

Across TCGA patient cohorts, DCUN1D1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCUN1D1-associated genes across cancer lineages are FOXO3a_pS318_S321, TIGAR, and C-Raf. Each is linked with DCUN1D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCUN1D1-to-partner and partner-to-DCUN1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by DCUN1D1-low versus DCUN1D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCUN1D1→partner) and Y-score (partner→DCUN1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.139	-2.212	.004	.010	3	2
UCEC	TIGAR →	+0.127	+2.026	.034	.005	3	2
UCEC	C-Raf →	+0.227	+2.807	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.137	-3.295	<.001	.009	3	1
UCEC	EGFR_pY1068 →	-0.317	-3.459	.001	.005	3	1
UCEC	eIF4E →	+0.250	+3.472	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

FOXO3a_pS318_S321 by DCUN1D1 expression — UCEC

Explore this box plot interactively →