DCTN5

Across TCGA patient cohorts, DCTN5 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCTN5-associated genes across cancer lineages are p62 Lck ligand, YB-1, and c-Kit. Each is linked with DCTN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCTN5-to-partner and partner-to-DCTN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by DCTN5-low versus DCTN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN5→partner) and Y-score (partner→DCTN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.412	+3.000	.028	.037	2	1
UCEC	YB-1 →	-0.204	-2.973	.026	.037	2	1
UCEC	c-Kit →	-0.266	-3.000	.048	.037	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p62 Lck ligand by DCTN5 expression — UCEC

Explore this box plot interactively →