DCTN4

Across TCGA patient cohorts, DCTN4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,022 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DCTN4-associated genes across cancer lineages are NAMPT, CEACAM3, and FAM83D. Each is linked with DCTN4 in more than 5 cancer types. Because this analysis shows association rather than direction, both DCTN4-to-partner and partner-to-DCTN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DCTN4 versus NAMPT in GBM, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN4→partner) and Y-score (partner→DCTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NAMPT →	-1.191	-0.216	<.001	<.001	3	6
UCEC	CEACAM3 →	-0.945	-0.289	<.001	<.001	3	5
HNSC	FAM83D →	-1.156	-0.265	<.001	.003	3	5
UCEC	PDZRN3 →	+0.951	+0.190	.001	.001	3	5
PDAC	FCGR3B →	-1.485	-0.324	<.001	<.001	3	5
HNSC	MAD2L1 →	-0.956	-0.272	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,022 associations by consensus.

DCTN4 vs NAMPT — GBM

Explore this scatter interactively →