DCTN4

Across TCGA patient cohorts, DCTN4 mutation is significantly associated with the RNA expression of many other genes, with 1,689 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCTN4-associated genes across cancer lineages are RNU6-492P, VRK1, and EMC9. Each is linked with DCTN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCTN4-to-partner and partner-to-DCTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-492P grouped by DCTN4-low versus DCTN4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN4→partner) and Y-score (partner→DCTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
UCEC	VRK1 →	+0.628	+3.467	.007	.002	3	2
UCEC	EMC9 →	+0.457	+3.346	.009	.005	3	2
UCEC	PFKFB4 →	+0.869	+3.592	<.001	.001	3	2
UCEC	EIF2B2 →	+0.615	+2.839	<.001	.001	3	2
UCEC	XRCC3 →	+0.571	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,689 associations by consensus.

RNU6-492P by DCTN4 expression — HNSC

Explore this box plot interactively →