DCTN4

Across TCGA cell cohorts, DCTN4 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DCTN4-associated genes across cancer lineages are CBY1, SH3GL2, and PPA2. Each is linked with DCTN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCTN4-to-partner and partner-to-DCTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by DCTN4-low versus DCTN4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN4→partner) and Y-score (partner→DCTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.912	+3.160	<.001	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.904	+3.474	<.001	.003	3	1
LARGE_INTESTINE	PPA2 →	+0.685	+3.064	.001	.009	3	1
LARGE_INTESTINE	SSMEM1 →	+0.024	+2.707	<.001	.003	3	1
LARGE_INTESTINE	CPLX4 →	+0.018	+3.252	.004	<.001	3	1
LARGE_INTESTINE	TNK1 →	+0.869	+3.064	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

CBY1 by DCTN4 expression — LARGE_INTESTINE

Explore this box plot interactively →