DCTN3

Across TCGA patient cohorts, DCTN3 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCTN3-associated genes across cancer lineages are RNA5SP109, RNU6-1169P, and IL9. Each is linked with DCTN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCTN3-to-partner and partner-to-DCTN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP109 grouped by DCTN3-low versus DCTN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCTN3→partner) and Y-score (partner→DCTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP109 →	+0.284	+4.137	<.001	.008	3	2
SKCM	RNU6-1169P →	+0.405	+5.362	<.001	.005	3	2
UCEC	IL9 →	+0.146	+3.384	<.001	.002	3	1
UCEC	CMC4 →	+0.036	+3.294	<.001	.007	3	1
UCEC	GAPDHP30 →	+0.164	+3.254	<.001	.002	3	1
UCEC	RNA5SP516 →	+0.446	+4.200	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

RNA5SP109 by DCTN3 expression — UCEC

Explore this box plot interactively →