DCT

Across TCGA patient cohorts, DCT mutation is significantly associated with the RNA expression of many other genes, with 1,748 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCT-associated genes across cancer lineages are TXN2, TMEM106C, and RNU6-484P. Each is linked with DCT in more than 3 cancer types. Because this analysis shows association rather than direction, both DCT-to-partner and partner-to-DCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXN2 grouped by DCT-low versus DCT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCT→partner) and Y-score (partner→DCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXN2 →	+0.290	+1.950	.003	.002	3	4
UCEC	TMEM106C →	+0.415	+1.652	.008	.006	3	3
LUAD	RNU6-484P →	+0.817	+2.720	<.001	.009	3	3
READ	FABP7 →	+0.153	+3.636	.007	.007	3	3
UCEC	IGHD5-12 →	+0.309	+2.479	<.001	.006	3	3
UCEC	ELOCP27 →	+0.285	+1.851	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,748 associations by consensus.

TXN2 by DCT expression — UCEC

Explore this box plot interactively →