DCT

Across TCGA cell cohorts, DCT RNA expression is significantly associated with the go_rna of many other GO terms, with 2,994 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DCT-associated GO terms across cancer lineages are Melanin biosynthetic process from tyrosine, Regulation of macrophage colony-stimulating factor production, and Cytoplasmic translation. Each is linked with DCT in more than 7 cancer types. Because this analysis shows association rather than direction, both DCT-to-partner and partner-to-DCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanin biosynthetic process from tyrosine grouped by DCT-low versus DCT-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCT→partner) and Y-score (partner→DCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Melanin biosynthetic process from tyrosine →	+1.568	+5.530	<.001	<.001	3	8
LIVER	Regulation of macrophage colony-stimulating factor production →	-1.404	-0.101	<.001	<.001	3	6
BREAST	Cytoplasmic translation →	+0.077	+0.131	<.001	.002	3	6
LARGE_INTESTINE	Regulation of syncytium formation by plasma membrane fusion →	+0.078	+0.248	<.001	<.001	3	6
BREAST	Protein modification by small protein removal →	+0.040	+0.161	<.001	<.001	3	6
PANCREAS	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.044	+0.074	.006	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,994 associations by consensus.

Melanin biosynthetic process from tyrosine by DCT expression — SKIN

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