DCT

Across TCGA cell cohorts, DCT mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DCT-associated genes across cancer lineages are GP9, CCDC172, and OR4S1. Each is linked with DCT in more than 1 cancer types. Because this analysis shows association rather than direction, both DCT-to-partner and partner-to-DCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GP9 grouped by DCT-low versus DCT-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCT→partner) and Y-score (partner→DCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GP9 →	+0.411	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CCDC172 →	+0.646	+5.209	<.001	.005	3	1
LUNG_SCLC	OR4S1 →	+0.020	+4.643	<.001	.004	3	1
OVARY	PRLHR →	+0.020	+2.859	<.001	.008	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+4.347	<.001	.001	3	1
LARGE_INTESTINE	TRARG1 →	+0.027	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GP9 by DCT expression — BLOOD_Lymphoma

Explore this box plot interactively →