DCT

Across TCGA cell cohorts, DCT mutation is significantly associated with the mutation status of many other genes, with 3,443 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCT-associated genes across cancer lineages are FLG2, MYH15, and PCDHB2. Each is linked with DCT in more than 4 cancer types. Because this analysis shows association rather than direction, both DCT-to-partner and partner-to-DCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLG2 grouped by DCT-low versus DCT-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCT→partner) and Y-score (partner→DCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FLG2 →	+3.257	+4.362	.005	.005	1	5
LARGE_INTESTINE	MYH15 →	+1.874	+3.700	.005	.005	1	5
PANCREAS	PCDHB2 →	+4.257	+4.906	.001	.001	1	4
SKIN	WNK1 →	+3.532	+3.357	.005	.005	1	4
SKIN	KIAA1109 →	+1.854	+2.995	.007	.007	1	4
SKIN	ENPEP →	+2.532	+3.604	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,443 associations by consensus.

FLG2 by DCT expression — PANCREAS

Explore this box plot interactively →