DCST2

Across TCGA patient cohorts, DCST2 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DCST2-associated genes across cancer lineages are ATM, Bad_pS112, and EGFR_pY1068. Each is linked with DCST2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DCST2-to-partner and partner-to-DCST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DCST2-low versus DCST2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCST2→partner) and Y-score (partner→DCST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.555	-3.308	.001	.009	3	4
COAD	Bad_pS112 →	-0.267	-3.576	.001	.002	3	3
COAD	EGFR_pY1068 →	-0.320	-3.000	.024	.034	3	2
COAD	HSP70 →	+0.739	+3.012	.002	.018	3	2
COAD	Lck →	+0.305	+2.484	.021	.010	3	2
COAD	Mre11 →	+0.168	+3.000	.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ATM by DCST2 expression — UCEC

Explore this box plot interactively →