DCST2

Across TCGA cell cohorts, DCST2 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DCST2-associated genes across cancer lineages are OR2T35, SH3GL2, and LHCGR. Each is linked with DCST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCST2-to-partner and partner-to-DCST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T35 grouped by DCST2-low versus DCST2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCST2→partner) and Y-score (partner→DCST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR2T35 →	+0.020	+5.614	<.001	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.387	+3.252	<.001	.009	3	1
LARGE_INTESTINE	LHCGR →	+0.023	+3.204	.006	<.001	3	1
LARGE_INTESTINE	FANCD2OS →	+0.104	+3.362	.003	.007	3	1
LARGE_INTESTINE	REG1B →	+2.243	+2.518	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

OR2T35 by DCST2 expression — PANCREAS

Explore this box plot interactively →