DCST1

Across TCGA patient cohorts, DCST1 mutation is significantly associated with the RNA expression of many other genes, with 2,161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCST1-associated genes across cancer lineages are RAB27A, MIR1228, and RPL23AP82. Each is linked with DCST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCST1-to-partner and partner-to-DCST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB27A grouped by DCST1-low versus DCST1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCST1→partner) and Y-score (partner→DCST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAB27A →	+0.617	+3.263	.008	.008	3	3
BLCA	MIR1228 →	+0.344	+5.311	<.001	.001	3	3
UCEC	RPL23AP82 →	+0.410	+2.928	<.001	<.001	3	3
COAD	C6orf118 →	+0.174	+4.085	<.001	<.001	3	2
COAD	GFI1 →	+1.610	+3.209	<.001	.009	3	2
COAD	NDC80 →	+0.750	+3.210	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,161 associations by consensus.

RAB27A by DCST1 expression — COAD

Explore this box plot interactively →