DCST1

Across TCGA patient cohorts, DCST1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCST1-associated genes across cancer lineages are GAPDH, ATM, and EGFR_pY1068. Each is linked with DCST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCST1-to-partner and partner-to-DCST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by DCST1-low versus DCST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCST1→partner) and Y-score (partner→DCST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.486	+1.440	.009	.024	3	3
UCEC	ATM →	-0.667	-2.986	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.277	-1.736	.001	.007	3	2
UCEC	eIF4E →	+0.192	+2.598	.008	.005	3	2
UCEC	mTOR_pS2448 →	-0.124	-2.202	.016	.010	3	2
UCEC	p62 Lck ligand →	+0.313	+2.331	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

GAPDH by DCST1 expression — UCEC

Explore this box plot interactively →