DCST1

Across TCGA cell cohorts, DCST1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,820 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible DCST1-associated GO terms across cancer lineages are Negative regulation of translational initiation, Pre-mRNA catabolic process, and Actomyosin contractile ring organization. Each is linked with DCST1 in more than 10 cancer types. Because this analysis shows association rather than direction, both DCST1-to-partner and partner-to-DCST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of translational initiation grouped by DCST1-low versus DCST1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCST1→partner) and Y-score (partner→DCST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of translational initiation →	+0.071	+0.139	<.001	<.001	3	11
BONE	Pre-mRNA catabolic process →	+0.191	+0.048	<.001	.008	3	10
KIDNEY	Actomyosin contractile ring organization →	+0.154	+0.090	<.001	<.001	3	10
BLOOD_Lymphoma	Regulation of myoblast fusion →	+0.066	+0.062	<.001	.001	3	9
BONE	Response to hypobaric hypoxia →	+0.134	+0.062	<.001	<.001	3	8
URINARY_TRACT	Cilium or flagellum-dependent cell motility →	-0.103	-0.180	.001	.002	1	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,820 associations by consensus.

Negative regulation of translational initiation by DCST1 expression — LARGE_INTESTINE

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