DCST1

Across TCGA cell cohorts, DCST1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DCST1-associated genes across cancer lineages are NCAN, CFHR2, and CNPY1. Each is linked with DCST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCST1-to-partner and partner-to-DCST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAN grouped by DCST1-low versus DCST1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCST1→partner) and Y-score (partner→DCST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NCAN →	+0.128	+3.629	.003	.003	3	2
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	2
SOFT_TISSUE	CNPY1 →	+0.140	+4.222	<.001	.007	3	1
SOFT_TISSUE	PSKH2 →	+0.193	+4.882	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
SKIN	C4BPA →	+0.037	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

NCAN by DCST1 expression — LARGE_INTESTINE

Explore this box plot interactively →