DCPS

Across TCGA patient cohorts, DCPS mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCPS-associated genes across cancer lineages are Myosin-IIa_pS1943, Shc_pY317, and Caspase-7-cleavedD198. Each is linked with DCPS in more than 1 cancer types. Because this analysis shows association rather than direction, both DCPS-to-partner and partner-to-DCPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by DCPS-low versus DCPS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCPS→partner) and Y-score (partner→DCPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.162	+2.013	.045	.005	3	2
UCEC	Shc_pY317 →	-0.143	-2.459	.016	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.562	+1.894	.015	.030	3	2
UCEC	EGFR_pY1068 →	-0.236	-2.700	.016	.006	3	1
UCEC	eIF4E →	+0.213	+2.700	.010	.006	3	1
UCEC	Ku80 →	+0.269	+2.515	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Myosin-IIa_pS1943 by DCPS expression — UCEC

Explore this box plot interactively →