DCP1A

Across TCGA patient cohorts, DCP1A mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCP1A-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and 4E-BP1. Each is linked with DCP1A in more than 2 cancer types. Because this analysis shows association rather than direction, both DCP1A-to-partner and partner-to-DCP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DCP1A-low versus DCP1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCP1A→partner) and Y-score (partner→DCP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.667	+2.827	.002	.001	3	3
UCEC	EGFR_pY1068 →	-0.238	-2.807	.009	.003	3	2
UCEC	4E-BP1 →	+0.275	+2.489	.005	.010	3	2
UCEC	Cyclin-B1 →	+0.438	+1.502	.034	.030	3	2
UCEC	eIF4E →	+0.222	+3.472	.004	.002	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.507	+2.594	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Caspase-7-cleavedD198 by DCP1A expression — UCEC

Explore this box plot interactively →