DCN

Across TCGA pan-cancer cohorts, DCN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DCN data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DCN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DCN expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where DCN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.105	0.928	.003	27	view →
LSCC	DFS	Quartile	II,III,IV	0.776	1.000	.011	15	view →
LUAD	DFS	Median	II,III,IV	0.757	0.949	.012	11	view →
UCEC	OS	Quartile	II,III,IV	0.519	1.000	.033	4	view →
GBM	DFS	Tertile	All	0.685	0.833	.012	3	view →
PDAC	DFS	Tertile	II,III,IV	0.853	0.630	.013	3	view →
HNSC	OS	Quartile	All	0.932	1.000	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DCN–CCRCC (DFS)

Open the CCRCC breakdown →