DCN

Across TCGA cell cohorts, DCN RNA expression is significantly associated with the go_rna of many other GO terms, with 1,728 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DCN-associated GO terms across cancer lineages are Negative regulation of endodermal cell differentiation, COPII-coated vesicle cargo loading, and Aorta morphogenesis. Each is linked with DCN in more than 7 cancer types. Because this analysis shows association rather than direction, both DCN-to-partner and partner-to-DCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endodermal cell differentiation grouped by DCN-low versus DCN-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCN→partner) and Y-score (partner→DCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of endodermal cell differentiation →	+1.368	+3.142	<.001	<.001	3	8
CNS	COPII-coated vesicle cargo loading →	+0.085	+1.762	<.001	.003	3	7
SOFT_TISSUE	Aorta morphogenesis →	+0.149	+4.260	.001	<.001	3	7
BONE	Extracellular matrix organization →	+0.243	+4.970	.001	<.001	3	7
BONE	Extracellular structure organization →	+0.246	+4.970	.001	<.001	3	7
BONE	External encapsulating structure organization →	+0.244	+4.969	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,728 associations by consensus.

Negative regulation of endodermal cell differentiation by DCN expression — LIVER

Explore this box plot interactively →