DCLRE1B

Across TCGA patient cohorts, DCLRE1B mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLRE1B-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with DCLRE1B in more than 1 cancer types. Because this analysis shows association rather than direction, both DCLRE1B-to-partner and partner-to-DCLRE1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DCLRE1B-low versus DCLRE1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1B→partner) and Y-score (partner→DCLRE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.420	+1.807	.004	.027	3	1
UCEC	EGFR_pY1068 →	-0.329	-2.700	.001	.006	3	1
UCEC	ERK2 →	+0.227	+3.169	.004	.018	3	1
UCEC	FoxM1 →	+0.240	+2.321	.024	.006	3	1
UCEC	GATA6 →	-0.201	-2.215	.002	.010	3	1
UCEC	ACVRL1 →	-0.184	-3.308	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eEF2 by DCLRE1B expression — UCEC

Explore this box plot interactively →