DCLRE1B

Across TCGA cell cohorts, DCLRE1B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,862 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DCLRE1B-associated GO terms across cancer lineages are Telomeric 3' overhang formation, Protection from non-homologous end joining at telomere, and Telomere maintenance in response to DNA damage. Each is linked with DCLRE1B in more than 19 cancer types. Because this analysis shows association rather than direction, both DCLRE1B-to-partner and partner-to-DCLRE1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomeric 3' overhang formation grouped by DCLRE1B-low versus DCLRE1B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1B→partner) and Y-score (partner→DCLRE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Telomeric 3' overhang formation →	+0.193	+1.522	<.001	<.001	3	20
BONE	Protection from non-homologous end joining at telomere →	+0.198	+1.469	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Telomere maintenance in response to DNA damage →	+0.118	+1.241	<.001	<.001	3	19
BONE	DNA replication checkpoint signaling →	+0.247	+1.356	<.001	<.001	3	18
BONE	DNA strand elongation →	+0.223	+1.438	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome segregation →	+0.167	+1.153	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,862 associations by consensus.

Telomeric 3' overhang formation by DCLRE1B expression — BONE

Explore this box plot interactively →