DCLRE1B

Across TCGA cell cohorts, DCLRE1B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DCLRE1B-associated genes across cancer lineages are OPRPN, OR1L6, and OR9I1. Each is linked with DCLRE1B in more than 1 cancer types. Because this analysis shows association rather than direction, both DCLRE1B-to-partner and partner-to-DCLRE1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by DCLRE1B-low versus DCLRE1B-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1B→partner) and Y-score (partner→DCLRE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OPRPN →	+0.139	+5.029	<.001	.006	3	1
LUNG_SCLC	OR1L6 →	+0.035	+5.029	<.001	.006	3	1
LUNG_SCLC	OR9I1 →	+0.023	+5.643	<.001	.002	3	1
LUNG_SCLC	URAD →	+0.044	+5.029	<.001	.006	3	1
LUNG_SCLC	LIPN →	+0.086	+5.643	<.001	.002	3	1
BLOOD_Leukemia	BEND2 →	+0.023	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OPRPN by DCLRE1B expression — LUNG_SCLC

Explore this box plot interactively →