DCLRE1B

Across TCGA cell cohorts, DCLRE1B mutation is significantly associated with the mutation status of many other genes, with 2,846 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCLRE1B-associated genes across cancer lineages are WDR62, KCNA6, and PRPF40A. Each is linked with DCLRE1B in more than 3 cancer types. Because this analysis shows association rather than direction, both DCLRE1B-to-partner and partner-to-DCLRE1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR62 grouped by DCLRE1B-low versus DCLRE1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLRE1B→partner) and Y-score (partner→DCLRE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR62 →	+2.284	+3.925	.005	.005	1	4
OVARY	KCNA6 →	+4.415	+4.977	.007	.007	1	4
OVARY	PRPF40A →	+4.415	+4.977	.007	.007	1	4
BLOOD_Leukemia	ATP13A2 →	+3.700	+4.498	<.001	<.001	1	4
STOMACH	TMEM266 →	+4.807	+4.807	.008	.008	1	4
OVARY	HNRNPL →	+5.415	+5.415	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,846 associations by consensus.

WDR62 by DCLRE1B expression — LARGE_INTESTINE

Explore this box plot interactively →