DCLK3

Across TCGA patient cohorts, DCLK3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLK3-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and GATA6. Each is linked with DCLK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCLK3-to-partner and partner-to-DCLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DCLK3-low versus DCLK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLK3→partner) and Y-score (partner→DCLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.291	+2.186	<.001	.032	3	3
UCEC	INPP4B →	-0.246	-1.678	.017	.019	3	3
UCEC	GATA6 →	-0.124	-2.570	.013	.010	3	2
UCEC	Heregulin →	-0.091	-1.687	.020	.040	3	2
UCEC	VHL →	-0.654	-1.662	.002	.010	3	2
UCEC	c-Kit →	-0.147	-1.289	.048	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by DCLK3 expression — COAD

Explore this box plot interactively →