DCLK3

Across TCGA cell cohorts, DCLK3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCLK3-associated genes across cancer lineages are PRAMEF18, OR1B1, and WNT8A. Each is linked with DCLK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCLK3-to-partner and partner-to-DCLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF18 grouped by DCLK3-low versus DCLK3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLK3→partner) and Y-score (partner→DCLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRAMEF18 →	+0.004	+4.415	<.001	.007	3	1
SKIN	OR1B1 →	+0.024	+4.467	<.001	.004	3	1
SKIN	WNT8A →	+0.021	+4.930	<.001	.001	3	1
LARGE_INTESTINE	CHRNA2 →	+0.070	+2.938	<.001	.003	3	1
LARGE_INTESTINE	CCDC54 →	+0.090	+2.669	.006	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PRAMEF18 by DCLK3 expression — SKIN

Explore this box plot interactively →