DCLK2

Across TCGA patient cohorts, DCLK2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLK2-associated genes across cancer lineages are PCNA, eIF4E, and MEK1. Each is linked with DCLK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCLK2-to-partner and partner-to-DCLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DCLK2-low versus DCLK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLK2→partner) and Y-score (partner→DCLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.269	+1.999	<.001	<.001	3	3
UCEC	eIF4E →	+0.201	+3.920	.001	<.001	3	2
UCEC	MEK1 →	+0.442	+2.273	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.114	-1.912	.011	.004	3	2
UCEC	Rad50 →	-0.155	-1.125	.034	.033	3	2
UCEC	Annexin-1 →	+0.626	+2.090	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PCNA by DCLK2 expression — UCEC

Explore this box plot interactively →