DCLK2

Across TCGA cell cohorts, DCLK2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DCLK2-associated genes across cancer lineages are AVP, ASPN, and OMD. Each is linked with DCLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DCLK2-to-partner and partner-to-DCLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by DCLK2-low versus DCLK2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLK2→partner) and Y-score (partner→DCLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
LARGE_INTESTINE	ASPN →	+0.047	+3.378	<.001	.006	3	1
LARGE_INTESTINE	OMD →	+0.046	+3.374	<.001	.005	3	1
LARGE_INTESTINE	BRDT →	+0.093	+3.906	<.001	.002	3	1
LARGE_INTESTINE	RASGEF1C →	+0.240	+3.555	.001	.003	3	1
LARGE_INTESTINE	RSC1A1 →	+0.740	+3.782	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

AVP by DCLK2 expression — BLOOD_Lymphoma

Explore this box plot interactively →