DCLK1

Across TCGA pan-cancer cohorts, DCLK1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DCLK1 data layer compared with 23 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DCLK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DCLK1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where DCLK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	IV	0.198	0.887	.024	20	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	12	view →
PDAC	OS	Tertile	III,IV	0.917	0.585	.006	7	view →
GBM	OS	Tertile	All	0.197	0.565	.011	6	view →
LUAD	DFS	Median	II,III,IV	0.592	0.307	.048	2	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →
LSCC	DFS	Quartile	II,III,IV	0.843	1.000	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DCLK1–CCRCC (DFS)

Open the CCRCC breakdown →