DCLK1

Across TCGA patient cohorts, DCLK1 mutation is significantly associated with the RNA expression of many other genes, with 4,371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCLK1-associated genes across cancer lineages are PBK, UQCRH, and CENPU. Each is linked with DCLK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DCLK1-to-partner and partner-to-DCLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by DCLK1-low versus DCLK1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLK1→partner) and Y-score (partner→DCLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PBK →	+1.095	+2.999	<.001	.001	3	4
UCEC	UQCRH →	+0.662	+2.233	<.001	<.001	3	4
UCEC	CENPU →	+0.555	+1.434	<.001	<.001	3	4
SKCM	ZFYVE19 →	+0.475	+3.214	.004	.009	3	4
UCEC	TYMS →	+0.599	+2.190	<.001	<.001	3	4
LUAD	CMC2 →	+0.484	+4.087	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,371 associations by consensus.

PBK by DCLK1 expression — LUAD

Explore this box plot interactively →