DCLK1

Across TCGA cell cohorts, DCLK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,650 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DCLK1-associated GO terms across cancer lineages are Regulation of metaphase plate congression, Dorsal root ganglion development, and Dentate gyrus development. Each is linked with DCLK1 in more than 7 cancer types. Because this analysis shows association rather than direction, both DCLK1-to-partner and partner-to-DCLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase plate congression grouped by DCLK1-low versus DCLK1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCLK1→partner) and Y-score (partner→DCLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of metaphase plate congression →	+0.121	+1.194	.002	.004	3	8
LIVER	Dorsal root ganglion development →	+0.231	+1.737	.002	.001	3	8
BREAST	Dentate gyrus development →	+0.107	+1.031	.002	<.001	3	7
OVARY	Response to oscillatory fluid shear stress →	+0.113	+1.515	.001	<.001	3	7
OVARY	Cellular response to oscillatory fluid shear stress →	+0.113	+1.515	.001	<.001	3	7
OVARY	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.113	+1.515	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,650 associations by consensus.

Regulation of metaphase plate congression by DCLK1 expression — SKIN

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